Wan Suriana WAN AB RAHMAN1,4, Wan Majdiah WAN MOHAMAD1,4, Abu Dzarr GANESH ABDULLAH2,4, Mohd Nazri HASSAN3,4, Zefarina ZULKAFLI3,4, Shafini YUSOF3,4, Salfarina IBERAHIM3,4, Noor Haslina MOHD NOOR3,4, Rosnah BAHAR3,4, Marini RAMLI3,4, Marne ABDULLAH3,4.
1School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia.
2Department of Medicine, School of Medical Science, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia.
3Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia.
4Hospital Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia.
ABSTRACT
The association of paraneoplastic rheumatic disorder and acute lymphoblastic leukaemia is rarely reported in the adolescent male. The clinical manifestations develop within two years before the diagnosis of associated malignancy. We report a case of an 18-year-old male, who presented with pyrexia of unknown origin, bicytopenia and autoantibodies that was consistent with the diagnosis of systemic lupus erythematosus. The peripheral blood film was eventually consistent with pancytopenia, devoid of any dysplastic changes or abnormal cells. When his cytopenia persisted despite empirical steroid therapy, a trephine biopsy revealed a diagnosis of acute lymphoblastic leukaemia. He was started on chemotherapy with UKALL regime and was well in his recent follow-up early this year where he was on maintenance therapy.
Keywords: Acute lymphoblastic leukaemia, Autoimmune, Paraneoplastic syndrome, Rheumatic disorder, Systemic lupus erythematosus.
Paraneoplastic Rheumatic Disorder In Acute Leukaemia: Diagnostic Conundrum
Corresponding Author
- Dr Wan Suriana Ab Rahman, School of Dental Sciences
- Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
- +609-7675831
- +609-7675505
- suriana@usm.my
